In 1982 the NCI-H460 cell line was discovered using the cells of a male patient with large cell lung carcinoma. These cells exhibit epithelial cellular morphology, are tumorigenic and express p53 mRNA similar to normal lung cells. This tumorigenic cell line is particularly unique in that it expresses no different structural DNA abnormalities, and its modal chromosome number of 57 makes it ideal for lung cancer research. The NCI-H460 cell line is typically used in molecular and biomedical lung cancer research. Altogen Biosystems manufactures a high efficiency lipid-based transfection reagent to facilitate these studies. Transfection Reagent for NCI-H460 Cells (Lung Carcinoma Cells, HTB-177)