In 1982 the NCI-H460 cell line was discovered using the cells of a male patient with large cell lung carcinoma. These cells exhibit epithelial cellular morphology, are tumorigenic and express p53 mRNA similar to normal lung cells. This tumorigenic cell line is particularly unique in that it expresses no different structural DNA abnormalities, and its modal chromosome number of 57 makes it ideal for lung cancer research. The NCI-H460 cell line is typically used in molecular and biomedical lung cancer research. Altogen Biosystems manufactures a high efficiency lipid-based transfection reagent to facilitate these studies.
Altogen Biosystems is a recognized developer and laboratory for biological laboratories. Custom research offers and additional preclinical items include xenografts, toxicology assays, 28-day generation of stably-transfected cells, liposome encapsulation and more. Dedicated to assisting pharmaceutical companies with cutting-edge and excellent services, Altogen Biosystems endeavors to optimize modern laboratory technologies. Visit Altogen’s website for a list of lung xenograft models .